Rejuran or Re2O: Which Fits My Skin Concern?
Rejuran is a skin booster that injects a PN ingredient obtained from salmon DNA into the dermis, and Re2O injects an active ingredient that reinforces the skin's support structure (ECM). Myongji Best Plastic Surgery Clinic in Myeongji-dong, Busan compares the two head to head: selection criteria by concern, pain and bumps, treatment schedules such as 2-3 sessions 4 weeks apart, and published fees.
Quick answer
Myongji Best Plastic Surgery Clinic in Myeongji-dong, Busan compares the PN skin booster Rejuran first when inner dryness, poor texture and fine lines appear together across the face or when an area-specific formulation is needed, such as for the eye area or sunken scars, and compares the ECM skin booster Re2O first when enlarged-looking pores and loss of firmness and skin density are the main concern. Re2O is recommended as 2-3 sessions 4 weeks apart; Rejuran has no fixed interval in the clinic's published materials, but in general, three PN injection sessions 4 weeks apart is the most commonly recommended approach. Which one hurts less, and whether the two can be received together, are not addressed in the clinic's published materials and are confirmed at consultation.
Why it matters now
Rejuran and Re2O are both skin boosters injected into the dermis, and they share many concerns, such as fine lines, firmness and dryness, so they are hard to tell apart by name alone. Rejuran conditions the environment inside the skin with a PN ingredient and divides its product line (Healer, HB, I, S) by area, while Re2O reinforces the skin's support structure (ECM) and sets injection depth and volume according to skin thickness and the firmness pattern of each area. The recommended number of sessions and per-session cost also differ, so deciding which concern is bigger comes first before you can plan the total cost and when to assess results.
Which is your main concern: inner dryness and fine lines around the eyes, or pores and loss of firmness?
If inner dryness, poor texture and fine lines appear together across the face, look first at Rejuran Healer; if enlarged-looking pores and loss of firmness and skin density are the main concern, look first at Re2O. For thin-skinned areas such as under the eyes there is Rejuran I, an eye-specific formulation, and for Re2O the clinic advises that bumps may appear in the thin skin around the eyes.
| If this is your situation | Approach to consider | Evidence and limits |
|---|---|---|
| Inner dryness, poor texture and fine lines together across the face | Approach to considerRejuran Healer (PN) | Evidence and limitsMyongji Best Plastic Surgery Clinic considers Rejuran Healer when loss of moisture-oil balance, poor texture and loss of firmness appear across the face together with fine lines. The clinic's published materials give no fixed interval, and in a survey of Korean dermatologists, three PN injection sessions 4 weeks apart was the most commonly recommended approach. |
| Enlarged-looking pores and loss of skin firmness and density | Approach to considerRe2O (ECM) | Evidence and limitsThe clinic lists improved firmness and density and improved pores and texture as expected effects of Re2O. It recommends 2-3 sessions 4 weeks apart, and with individual variation, firmness changes can be felt from 2-4 weeks. |
| Loss of firmness that differs by area, such as the front cheeks, cheekbones and mouth area | Approach to considerRe2O (injection depth and volume adjusted by area) | Evidence and limitsInjection depth and volume are adjusted considering skin thickness, the condition of the dermis and the firmness pattern of the front cheeks, cheekbones and mouth area. How much of the 6cc goes to which area is decided at consultation. |
| Fine lines under the eyes and thinning eye-area skin | Approach to considerRejuran I (eye-specific formulation) | Evidence and limitsRejuran I is an eye-specific formulation. For Re2O, the clinic advises that bumps may appear in the thin skin around the eyes. |
| Deep pitted acne scars, localized wrinkles and marked skin unevenness | Approach to considerRejuran S | Evidence and limitsA concentrated formulation for scars and localized areas with higher PN concentration and viscosity. The Re2O page does not list scars as a target concern, and Rejuran S has no published fee, so it is confirmed at consultation. |
| Inner dryness and dullness, with worry about injection pain | Approach to considerRejuran HB (PN + hyaluronic acid + lidocaine) | Evidence and limitsA formulation that adds hyaluronic acid and lidocaine to PN, considered when you want to reduce the burden of pain. The anesthesia method for Re2O is not in the published materials, so it is confirmed at consultation. |
How do Rejuran's PN and Re2O's ECM differ?
Rejuran injects a PN ingredient extracted and purified from salmon DNA into the dermis, while Re2O injects an active ingredient into the dermis to reinforce the ECM structure in the skin. According to the clinic, Rejuran conditions the environment inside the skin to manage texture, inner dryness, fine lines and firmness together, while Re2O reinforces the skin's support structure to manage firmness, density, pores, texture, skin tone and radiance, and hydration.
PN (Rejuran)
An ingredient extracted and purified from salmon DNA. Choosing the product that fits the skin concern and treated area from four lines (Healer, HB, I and S) is what differs most from Re2O.
ECM (Re2O)
ECM is the skin's support structure, made up of collagen, elastin, hyaluronic acid and other components, and it affects skin firmness, texture and the moisture environment. Rather than switching products, injection depth and volume are adjusted to skin thickness and the firmness pattern of each area.
Re2O's raw material (per the manufacturer and research)
The manufacturer, L&C Bio, describes Re2O as a human tissue product made by micronizing acellular dermal allograft (hADM), composed of the ECM components that make up real skin, such as collagen, elastin, proteins and proteoglycans. The 2026 study that tested Re2O also describes the product as ECM made into particles by removing cells from human dermal tissue (phADM).
What the two treatments have in common
Both are injected into the dermis, and swelling and bruising may appear temporarily after treatment, according to the clinic. For Re2O, the clinic advises that firmness changes can be felt from 2-4 weeks, so results are not judged by how the skin looks right after treatment.
Is Re2O less painful than Rejuran? Which causes more bumps?
Myongji Best Plastic Surgery Clinic's published materials do not compare the pain or bumps of the two treatments, and we found no directly verified published data from studies comparing the pain of the two products head to head. So the claim that Re2O hurts less is hard to treat as an established fact, and if pain worries you, it is more accurate to ask first about the anesthesia method and formulation at consultation.
Rejuran is injected into the dermis after numbing cream is applied, and when you want to reduce the burden of pain, Rejuran HB with added lidocaine is considered. For Re2O, the clinic's published materials do not state an anesthesia method.
The Re2O page advises that bumps may appear in the thin skin around the eyes, while the Rejuran page advises that redness, swelling and bruising may appear temporarily. In a 15-person study that used Rejuran I as the control product for fine lines around the eyes, bumps appeared in 34 of 60 injections (56.7%) on the Rejuran I side, but that study did not compare it with Re2O.
How does Myongji Best Plastic Surgery Clinic in Myeongji-dong, Busan perform the two treatments, and how do the costs differ?
Myongji Best Plastic Surgery Clinic in Myeongji-dong, Gangseo-gu, Busan performs Rejuran in the order of consultation and diagnosis, cleansing, numbing cream application, dermal injection and soothing care, choosing a product from Healer, HB, I and S. For Re2O, injection depth and volume are adjusted considering skin thickness, the condition of the dermis and the firmness pattern of the front cheeks, cheekbones and mouth area, and 2-3 sessions 4 weeks apart are recommended.
The fees below are based on Myongji Best Plastic Surgery Clinic's published non-covered fee information (checked November 2, 2026). Re2O is recommended as 2-3 sessions 4 weeks apart and no multi-session package price is published, so the total cost including the number of sessions is confirmed at consultation; non-covered fees may change.
| Item | Published fee | Notes |
|---|---|---|
| Elravie Re2O 6cc | Published feeKRW 770,000 per session | Notes2-3 sessions 4 weeks apart recommended; no multi-session package price is published |
| Rejuran HB 2cc | Published feeKRW 450,000 per session | NotesA formulation that adds hyaluronic acid and lidocaine to PN |
| Rejuran I 1cc | Published feeKRW 159,000 per session | NotesEye-specific formulation |
| Rejuran Healer and Rejuran S | Published feeNo published fee | NotesConfirmed at consultation |
| Number of Rejuran sessions | Published feeNo fixed interval in the clinic's published materials | NotesIn general, three sessions 4 weeks apart is most commonly recommended, and some studies used three sessions 2 weeks apart; the clinic's number of sessions and total cost are planned at consultation |
What are the actual results and side effects of Rejuran and Re2O in numbers?
Myongji Best Plastic Surgery Clinic has no published data on Rejuran or Re2O results or side-effect statistics. For Re2O there is one 20-person split-face study that tested the product itself, and for Rejuran there is a 15-person pain study that used Rejuran I as the control product and a systematic review covering PN studies overall, but we found no directly verified published data from studies comparing the two products head to head.
Myongji Best Plastic Surgery Clinic data
Treatment results and side effect statistics: no published data
Lee et al., 2026 (Re2O, randomized double-blind split-face, 20 people)
Twenty adults with moderately rough cheek texture received Re2O on one side of the face and a non-cross-linked hyaluronic acid skin booster on the other, with measurements over 20 weeks. The Re2O side improved more at several time points in skin density, firmness, wrinkle depth, pore area and hydration measures, and there were no serious adverse events. Each side received 1.5mL by an automated injector, which differs from the clinic's plan of 6cc in 2-3 sessions 4 weeks apart; the test product contained a non-cross-linked hyaluronic acid carrier, and one author advised on the development of Re2O.
Jeon et al., 2026 (Rejuran I control, randomized patient-blinded split-face, 15 people)
For fine lines around the eyes, Rejuran I was injected on one side and a different PN product with adjusted pH and ionic concentration on the other, four times at 2-week intervals. Pain on a 10-point scale averaged 5.04 on the Rejuran I side and 3.39 on the adjusted-product side; bumps appeared in 56.7% and 13.3% and redness in 60% and 40%, respectively, and wrinkle improvement did not differ between sides. The manufacturer of the comparison product funded the study, and it did not compare with Re2O.
Lampridou et al., 2025 (systematic review, 9 studies, 219 people)
Pooling nine PN injection studies, the review found reported improvements in wrinkles, texture and firmness, with side effects that were generally mild and temporary. The included studies were of low to moderate quality and varied in injection areas and methods, so the authors concluded that consensus on optimal use is still lacking.
Rejuran vs Re2O head to head
Studies directly comparing the efficacy, pain and side effects of the two products: no directly verified published data
Points to keep in mind about the numbers
Each clinical study was small, with 20 people or fewer and follow-up of 20 weeks or less, and the injection volume, interval and area differ from the clinic's treatments, so the results cannot be applied directly.
How should I care for my skin after treatment, and when should I return to the clinic?
After Rejuran, redness, swelling and bruising may appear temporarily and usually ease within a few days; keep face washing and makeup to a minimum on the day and avoid saunas and strenuous exercise for about 7 days. After Re2O, swelling, bruising and redness may occur temporarily; avoid saunas, jjimjilbang, alcohol and smoking for about 1 week, and keep up moisturizing and sun protection.
Care after Rejuran
Keep face washing and makeup to a minimum on the day, avoid saunas and strenuous exercise for about 7 days, and be thorough with sun protection.
Care after Re2O
Avoid saunas, jjimjilbang, alcohol and smoking for about 1 week, and keep up moisturizing and sun protection.
Next session schedule
For Re2O, the next visit is booked to fit the recommended schedule of 2-3 sessions 4 weeks apart. Rejuran has no fixed interval in the clinic's published materials, so the schedule is set at consultation; in general, three sessions 4 weeks apart is most commonly recommended, and some studies used 2-week intervals.
When to contact the clinic right away
If redness, swelling or bruising does not settle after a few days or gets worse, contact the clinic to be checked rather than waiting for your next appointment.
Suitability, product and volume, and whether to combine the two treatments depend on skin condition and the medical team's judgment, so prioritize your doctor's diagnosis and guidance over general information online. The general intervals, periods and volumes in this article are reference values based on published research and product information, and the exact values for you are confirmed at consultation.
Frequently asked questions
What is the difference between Rejuran and Re2O
Rejuran is a skin booster that injects a PN ingredient extracted and purified from salmon DNA into the dermis, and Re2O injects an active ingredient that reinforces the ECM structure in the skin. Myongji Best Plastic Surgery Clinic uses Rejuran to manage texture, inner dryness, fine lines and firmness, and Re2O to manage firmness, density, pores and texture; with Rejuran a product line is chosen for each area, while with Re2O injection depth and volume are adjusted for each area.
Can Rejuran and Re2O be done together
Myongji Best Plastic Surgery Clinic's published materials do not address receiving Rejuran and Re2O on the same day or in the same area. In a survey of Korean dermatologists, PN injections were often combined with device treatments such as lasers, radiofrequency and HIFU, but we could not directly verify any study or manufacturer guidance on how to use PN and ECM skin boosters together or how far apart. Whether to combine them, and in what order, is decided at consultation based on skin condition.
What is the treatment schedule for Re2O
Myongji Best Plastic Surgery Clinic recommends Re2O as 2-3 sessions 4 weeks apart and advises that, with individual variation, firmness changes can be felt from 2-4 weeks. We could not directly verify any study or manufacturer guidance that sets a maintenance interval after that, and the study that tested Re2O observed patients only up to 20 weeks, so the timing of maintenance is decided at consultation based on progress.
About the clinic behind this article
Myongji Best Plastic Surgery Clinic is a board-certified plastic surgery clinic in Myeongji-dong, Gangseo-gu, Busan. Dr. Hyungseok Noh, board-certified plastic surgeon and medical director, provides care.
- Address
- Units 302–305, Building 1, 3 Myeongji-gukje 2-ro 28beon-gil, Gangseo-gu, Busan
- Main Line
- 051-711-7991
- Clinic Hours
- Weekdays AM 10:00 ~ PM 07:30Saturday AM 10:00 ~ PM 03:00Sundays & Public Holidays Closed
- Treatment guide
- View the Re2O page
- Booking
- Naver Booking
REFERENCES
References
This article uses the clinic’s published information together with authoritative medical sources.
- Myongji Best Plastic Surgery ClinicRejuran information — ingredient and product line
Supports: PN ingredient and injection layer, target concerns, uses of the Healer, HB, I and S products
Rejuran is a skin booster that injects a PN ingredient extracted and purified from salmon DNA into the dermis. / It looks at texture, inner dryness, fine lines and loss of firmness together and can help restore overall skin condition. / Considered when loss of moisture-oil balance, texture and firmness across the face appears together with fine lines. / Hyaluronic acid and lidocaine are added to PN; considered when you want to manage inner dryness and dullness while reducing the burden of pain. / Rejuran I is an eye-specific formulation used for delicate areas such as fine lines under the eyes, thinning eye-area skin and loss of firmness around the eyes. / Rejuran S is a concentrated formulation for scars and localized areas, used for deep pitted acne scars, localized wrinkles and areas with marked skin unevenness.
- Myongji Best Plastic Surgery ClinicRejuran information — treatment details and aftercare
Supports: Anesthesia method, treatment steps, post-treatment reactions and daily care
Consultation and diagnosis → cleansing → numbing cream application → dermal injection → soothing care / Redness, swelling and bruising may appear temporarily and usually ease within a few days / Please keep face washing and makeup to a minimum on the day / Please avoid saunas and strenuous exercise for about 7 days / Please be thorough with sun protection
- Myongji Best Plastic Surgery ClinicRe2O information — ECM structure and expected effects
Supports: ECM structural reinforcement, ECM composition, target concerns and expected effects, injection depth and volume adjusted by area
Elravie Re2O is a skin booster that reinforces the ECM structure in the skin. / ECM is the skin's support structure, made up of collagen, elastin, hyaluronic acid and other components. / It affects skin firmness, texture and the moisture environment. / Improved skin firmness and density / Improved pores and texture / Injection depth and volume are adjusted considering skin thickness, the condition of the dermis and the firmness pattern of the front cheeks, cheekbones and mouth area.
- Myongji Best Plastic Surgery ClinicRe2O information — treatment details and aftercare
Supports: Recommended schedule, when improvement is felt, temporary reactions, eye-area bumps and post-treatment precautions
2-3 sessions 4 weeks apart recommended / With individual variation, firmness improvement can be felt from 2-4 weeks / Swelling, bruising and redness may appear temporarily / Bumps may appear in the thin skin around the eyes. / Avoid saunas, jjimjilbang, alcohol and smoking for about 1 week. / Keep up moisturizing and sun protection.
- Myongji Best Plastic Surgery ClinicNon-covered fee schedule
Supports: Published per-session fees for Elravie Re2O 6cc, Rejuran HB 2cc and Rejuran I 1cc
Elravie Re2O 6cc KRW 770,000 per session, Rejuran HB 2cc KRW 450,000 per session, Rejuran I 1cc KRW 159,000 per session
- L&C Bio (manufacturer)Re2O® product information
Supports: Re2O's raw material (micronized acellular dermal allograft), ECM composition and classification as human tissue
Re2O® Re2O human tissue … Re2O® is a product made by micronizing hADM (Human Acellular Dermal Matrix, acellular dermal allograft) and is composed of ECM (Extra Cellular Matrix) components that make up real skin, such as collagens, elastin, proteins and proteoglycans.
- PubMedA survey on the cosmetic use of injectable polynucleotide: The pattern of practice among Korean Dermatologists
Rho NK, Han KH, Cho M, Kim HS. A survey on the cosmetic use of injectable polynucleotide: The pattern of practice among Korean Dermatologists. J Cosmet Dermatol. 2024;23(4):1243-1252. doi:10.1111/jocd.16125. PMID: 38093498
Supports: Most commonly recommended number and interval of PN injection sessions, and the share combining them with device treatments, in a survey of 235 Korean dermatologists
A total of 235 Korean board-certified dermatologists familiar with skin boosters participated in a survey which questioned the participant's years of practice, selection of skin boosters in one's clinic, and range of lasers and light sources as well as skin care devices that are available. … A total of three sessions of PN injection spaced 4 weeks apart is most often recommended. 79 percent of PN users blended PN injection with lasers and light therapy with the most popular being radiofrequency (non-invasive, needle RF) and high-intensity focused ultrasound (HIFU).
- PubMedComparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial
Lee YJ, Kim HT, Lee YJ, et al. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. J Dermatolog Treat. 2022;33(1):254-260. doi:10.1080/09546634.2020.1748857. PMID: 32248707
Supports: Treatment interval in an eye-area split-face study that gave PN injections as three sessions 2 weeks apart
Each subject received filler injections thrice with two-week intervals, with a PN filler injection on one side and a non-crosslinked hyaluronic acid (HA) filler injection on the contralateral side of the periorbital area.
- PubMedInjectable Particulated Human Acellular Dermal Matrix Booster for Skin Restoration: An Integrated Randomized, Split-Face, Double-Blinded Clinical Trial and Preclinical Study
Lee YI, Chau NH, Nguyen NH, Ham S, Baek Y, Kim J, Lee JH. Injectable Particulated Human Acellular Dermal Matrix Booster for Skin Restoration: An Integrated Randomized, Split-Face, Double-Blinded Clinical Trial and Preclinical Study. Int J Mol Sci. 2026;27(5):2193. doi:10.3390/ijms27052193. PMID: 41828422
Supports: 20-person randomized double-blind split-face study comparing Elravie Re2O (confirmed in the test product section of the full text) with non-cross-linked hyaluronic acid
This randomized, split-face, double-blinded clinical trial evaluated the efficacy of phADM as a facial skin booster in 20 adults with moderate cheek roughness. phADM was injected on one facial side, with hyaluronic acid serving as the contralateral control. Multiple skin parameters were assessed over 20 weeks using validated imaging and biophysical instruments. … Clinically, the phADM-treated side demonstrated greater improvements in skin density, volume, elasticity, wrinkle depth, pore area, hydration, and barrier-related parameters at multiple time points compared with HA. … No serious adverse events were observed during the clinical study.
- PubMedEfficacy of Ionization-Adjusted PN Filler in Minimizing Injection Pain: A Randomized, Patient-Blinded, Split-Face Study
Jeon W, Park M, Kim SW, Kim J. Efficacy of Ionization-Adjusted PN Filler in Minimizing Injection Pain: A Randomized, Patient-Blinded, Split-Face Study. Aesthetic Plast Surg. 2026;50(7):2723-2730. doi:10.1007/s00266-025-05320-x. PMID: 41361144
Supports: 15-person split-face study comparing pain, bumps and redness between Rejuran I (confirmed in the control product section of the full text) and an ion-adjusted PN product
The ionized PN filler demonstrated significantly lower pain scores (VAS 3.39 ± 1.81) compared to the conventional filler (VAS 5.04 ± 2.19, p < 0.005), with fewer cases of erythema (40% vs. 60%) and embossing (13.3% vs. 56.7%).
- PubMedThe Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review
Lampridou S, Bassett S, Cavallini M, Christopoulos G. The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review. J Cosmet Dermatol. 2025;24(2):e16721. doi:10.1111/jocd.16721. PMID: 39645667
Supports: Summary of efficacy, side effects and level of evidence from a systematic review pooling 9 PN injection studies and 219 people
Nine studies, of low and moderate quality, were included in this review, describing a population of 219 patients receiving PN treatment. … While side effects are generally mild and transient, patient satisfaction is moderate to high, suggesting PN treatment as a well-tolerated and effective cosmetic intervention.
Published 2026.11.03Last updated 2026.11.03