If skin texture, firmness and inner dryness are your concerns, which fits best: Rejuran, Juvelook, Re2O or Hilo Wave?
Skin boosters fall into groups by main ingredient: PN (Rejuran), PDLLA (Juvelook), hyaluronic acid (Hilo Wave) and ECM (Re2O). Myongji Best Plastic Surgery Clinic in Myeongji-dong, Busan compares how to choose by texture, firmness and inner-dryness concerns, along with treatment cycles and published fees.
Quick answer
If poor texture, inner dryness and fine lines appear together across the face, compare the PN skin booster Rejuran first; if sunken acne scars or enlarged pores and loss of firmness are the concern, compare Juvelook with PDLLA; and if skin that dries and feels tight easily is the main issue, compare the hyaluronic acid skin booster Hilo Wave. To manage firmness and skin density from the side of the skin's support structure (ECM), Re2O is considered. All four are injected into the dermis, and most are repeated several times at 3-4 week or 4-week intervals before results are assessed.
Why it matters now
Skin boosters share the same dermal injection approach despite their different names, but their main ingredients differ (PN, PDLLA, hyaluronic acid, ECM), so the expected role and recommended number of sessions also differ. Choosing by name or per-session price alone can mismatch the goal, for example picking a product meant for sunken scars when inner dryness is the main problem. Most produce gradual change over several sessions, so decide your main concern and when results will be assessed before starting.
Which skin booster fits my skin concern?
If inner dryness, texture and fine lines appear together, look first at the PN group (Rejuran); if sunken areas and pores are the concern, the PDLLA group (Juvelook); and if dryness and tightness are central, the hyaluronic acid group (Hilo Wave). For thin-skinned areas such as around the eyes, also check whether a dedicated formulation exists and the possibility of bumps.
| If this is your situation | Option to consider | Evidence and limits |
|---|---|---|
| Poor texture, inner dryness, fine lines and loss of firmness together across the face | Option to considerRejuran Healer (PN) | Evidence and limitsMyongji Best Plastic Surgery Clinic uses PN skin boosters to manage texture, dryness, fine lines and firmness. Rejuran has no fixed cycle in the published information, so the number of sessions is set at consultation. |
| Inner dryness and dullness, with worry about injection pain | Option to considerRejuran HB | Evidence and limitsA formulation that adds hyaluronic acid and lidocaine to PN. How much pain is felt varies from person to person. |
| Fine lines under the eyes and thinned skin around the eyes | Option to considerRejuran I (eye-area formulation) | Evidence and limitsA formulation used for delicate areas such as around the eyes. With Re2O, bumps may appear in the thin skin around the eyes. |
| Sunken acne scars and uneven skin, with enlarged pores and loss of firmness | Option to considerJuvelook (PDLLA) or Rejuran S | Evidence and limitsPDLLA breaks down slowly and induces an environment for collagen production, so change is gradual. Several sessions at 3-4 week intervals are recommended. |
| Skin that dries and tightens easily, with skincare alone not moisturizing enough | Option to considerHilo Wave (hyaluronic acid) | Evidence and limitsManages the moisture environment with high- and low-molecular-weight hyaluronic acid. According to the clinic, changes in texture and firmness can be felt after 2-3 weeks. |
| Loss of firmness and density, with pores that look enlarged | Option to considerRe2O (ECM) | Evidence and limitsDescribed as a skin booster that reinforces the skin's support structure. No directly verified published clinical figures for the product itself were found. |
How do PN, PDLLA, hyaluronic acid and ECM skin boosters differ?
All four are injected into the dermis, but their main ingredients differ. PN focuses on the skin's regenerative environment, PDLLA on a gradually building collagen-production environment, hyaluronic acid on the moisture environment, and ECM on the skin's support structure.
PN (Rejuran)
Rejuran uses PN extracted and purified from salmon DNA. The product is chosen from Healer, HB, I and S to suit the concern and area.
PDLLA and hyaluronic acid (Juvelook)
PDLLA breaks down slowly in the skin and induces an environment for collagen production, while hyaluronic acid helps supplement hydration right after treatment. It is used on the whole face, neck and backs of the hands.
Hyaluronic acid (Hilo Wave)
Low-molecular-weight hyaluronic acid helps deliver moisture to deeper layers, and high-molecular-weight hyaluronic acid helps form a moisture barrier in the surface layer. Myongji Best Plastic Surgery Clinic also uses it to support contours in areas such as under-eye hollows and nasolabial folds.
ECM (Re2O)
ECM is the skin's support structure, made up of collagen, elastin, hyaluronic acid and more. The injection depth and volume are set by looking at skin thickness and the firmness of the front cheeks, cheekbones and mouth area.
How do skin booster cycles and costs differ at Myongji Best Plastic Surgery Clinic?
Per-session costs range from KRW 159,000 for Rejuran I 1cc to KRW 770,000 for Elravie Re2O 6cc, and the recommended number of sessions also differs, so total cost should be compared by multiplying by the number of sessions. Re2O is recommended 2-3 times at 4-week intervals, Juvelook several times at 3-4 week intervals, and Hilo Wave 3 or more times at 3-4 week intervals.
The fees below are based on Myongji Best Plastic Surgery Clinic's published non-covered fee information (checked October 20, 2026). Volume, treatment area and whether numbing cream and soothing care are included are confirmed as a total cost at consultation, and non-covered fees may change.
| Treatment | Recommended cycle / anesthesia | Published fee |
|---|---|---|
| Rejuran | Recommended cycle / anesthesiaNo fixed cycle in the published information; numbing cream | Published feeHB 2cc KRW 450,000; I 1cc KRW 159,000 |
| Juvelook | Recommended cycle / anesthesiaSeveral times at 3-4 week intervals; numbing cream; time varies with the treated area | Published feeSkin 4cc: 1 session KRW 440,000, 3 sessions KRW 1,100,000; Volume 4cc: 1 session KRW 495,000, 3 sessions KRW 1,320,000 |
| RE2O | Recommended cycle / anesthesia2-3 times at 4-week intervals | Published fee6cc KRW 770,000 |
| Hilo Wave | Recommended cycle / anesthesia3 or more times at 3-4 week intervals; maintenance on a 4-6 month cycle considered; about 20-30 minutes; numbing ointment | Published feeKRW 550,000 |
Do recovery and precautions after a skin booster differ by product?
All four can cause temporary reactions such as redness, swelling, bruising or bumps, which the clinic says usually settle within a few days. However, the period for avoiding hot environments such as saunas differs by product, for example about 7 days for Rejuran and Re2O and at least 2-3 days for Hilo Wave.
Rejuran
Keep face washing and makeup to a minimum on the day, and avoid saunas and strenuous exercise for about 7 days.
Juvelook
Avoid vigorous face washing and massage on the day, and refrain from alcohol, saunas, jjimjilbang and strenuous exercise for several days.
RE2O
Avoid saunas, jjimjilbang, alcohol and smoking for about 1 week, and keep up moisturizing and sun protection.
Hilo Wave
Face washing and makeup may be restricted on the day, and avoid saunas, jjimjilbang, strenuous exercise and alcohol for at least 2-3 days.
If redness or pain keeps getting worse or an abnormal reaction persists, judgment depends on the treated area and skin condition, so have it checked by the medical team right away.
What are the actual results and side effects of skin boosters in numbers?
Myongji Best Plastic Surgery Clinic has no published data on skin booster results or side effects. Small overseas and Korean studies found improved skin texture, firmness and hydration measures with PN, a PDLLA-hyaluronic acid combination and non-cross-linked hyaluronic acid, with no serious adverse events reported, but most of the products studied are not the same as the clinic's products.
Myongji Best Plastic Surgery Clinic data
Treatment results and side-effect statistics: no published data
Lee et al., 2022 (randomized, double-blind, split-face, 27 people)
PN and non-cross-linked hyaluronic acid were injected around the eyes, one on each side of the face, 3 times at 2-week intervals. Overall aesthetic improvement scores did not differ between the groups, while improvement rates for elasticity, hydration, roughness and pores were higher on the PN side.
Lim et al., 2024 (single arm, 30 Asian participants)
Six months after 3 injections of a PN product at 4-week intervals, 33% rated themselves "Much Improved" and 43% "Very Much Improved," with no adverse events. The product was a different PN product, not Rejuran, and there was no control group.
Seo et al., 2024 (preliminary study, 16 people)
A PDLLA and non-cross-linked hyaluronic acid combination was injected 2-3 times at 4-week intervals, and 50% reported more than 50% overall improvement. There were no severe adverse events.
Duteil et al., 2023 (randomized, double-blind, split-face, 30 people)
Compared with the saline side, the non-cross-linked hyaluronic acid side showed a 35% increase in skin radiance and hydration and a 27% increase in firmness, and the investigator found improvement in 82%. The product was not Hilo Wave, and employees of the manufacturer were among the authors.
Re2O data
Efficacy and side-effect figures for the Re2O product: no directly verified published data
Points to note when reading the figures
All were small studies of 30 people or fewer with short follow-up, and the products and injection methods differ from the clinic's treatments, so the results cannot be applied directly.
Frequently asked questions
which skin booster should I get first
Start by deciding the one concern that bothers you most. For inner dryness and texture, choose the PN group or Hilo Wave; for sunken scars and pores, choose a matching group such as Juvelook; then decide the area and number of sessions at consultation.
when do skin booster results show
According to the clinic, firmness improvement with Re2O can be felt from 2-4 weeks, and texture and firmness improvement with Hilo Wave after 2-3 weeks, with individual variation. Bumps or swelling right after treatment are not judged as results.
how often do you need skin booster maintenance
Myongji Best Plastic Surgery Clinic advises considering maintenance for Hilo Wave on a 4-6 month cycle. Rejuran, Juvelook and Re2O have no separate maintenance cycle in the published information, so it is decided at consultation based on progress.
About the clinic behind this article
Myongji Best Plastic Surgery Clinic is a board-certified plastic surgery clinic in Myeongji-dong, Gangseo-gu, Busan. Dr. Hyungseok Noh, board-certified plastic surgeon and medical director, provides care.
- Address
- Units 302–305, Building 1, 3 Myeongji-gukje 2-ro 28beon-gil, Gangseo-gu, Busan
- Main Line
- 051-711-7991
- Clinic Hours
- Weekdays AM 10:00 ~ PM 07:30Saturday AM 10:00 ~ PM 03:00Sundays & Public Holidays Closed
- Treatment guide
- View the Rejuran page
- Booking
- Naver Booking
REFERENCES
References
This article uses the clinic’s published information together with authoritative medical sources.
- Myongji Best Plastic Surgery ClinicRejuran guide
Supports: PN ingredient and uses of the Healer, HB, I and S products, anesthesia method, aftercare
A skin booster that injects a PN ingredient extracted and purified from salmon DNA into the dermis.
- Myongji Best Plastic Surgery ClinicJuvelook guide
Supports: Roles of PDLLA and hyaluronic acid, target concerns and areas, treatment cycle and anesthesia, aftercare
Recommended several times at 3-4 week intervals, using numbing cream.
- Myongji Best Plastic Surgery ClinicRe2O guide
Supports: ECM composition, target concerns, recommended cycle and when improvement is felt, eye-area bumps and aftercare
Results vary by individual, but firmness improvement can be felt from 2-4 weeks.
- Myongji Best Plastic Surgery ClinicHilo Wave guide
Supports: Roles of high- and low-molecular-weight hyaluronic acid, target concerns, recommended cycle and maintenance, aftercare
Recommended 3 or more times at 3-4 week intervals, with maintenance considered on a 4-6 month cycle.
- Myongji Best Plastic Surgery ClinicNon-covered fee information
Supports: Published fees for Rejuran, Juvelook, Re2O and Hilo Wave
Elravie Re2O 6cc KRW 770,000, Hilo Wave KRW 550,000, Rejuran HB 2cc KRW 450,000
- PubMedComparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial
Lee YJ, Kim HT, Lee YJ, et al. J Dermatolog Treat. 2022;33(1):254-260. doi:10.1080/09546634.2020.1748857. PMID: 32248707
Supports: Split-face comparison of PN and non-cross-linked hyaluronic acid around the eyes in 27 people
Improvements in the visual analog scale and global esthetic improvement scale scores were not significantly different between the PN and HA groups.
- PubMedPolynucleotides HPT for Asian Skin Regeneration and Rejuvenation
Lim TS, Liew S, Tee XJ, et al. Clin Cosmet Investig Dermatol. 2024;17:417-431. doi:10.2147/CCID.S437942. PMID: 38371328
Supports: Six-month improvement ratings after 3 injections of a PN product in 30 Asian participants
At T4, 33% and 43% of treated subjects felt "Much Improved" and "Very Much Improved" (optimal result)
- PubMedSkin rejuvenation effect of the combined PDLLA and non cross-linked hyaluronic acid: A preliminary study
Seo SB, Park H, Jo JY, Ryu HJ. J Cosmet Dermatol. 2024;23(3):794-802. doi:10.1111/jocd.16085. PMID: 37969055
Supports: Improvement responses and safety of a PDLLA and non-cross-linked hyaluronic acid combination in 16 people
Half (50%) of patients responded that there was more than 50% overall improvement. There were no severe adverse events.
- PubMedThe Effects of a Non-crossed-linked Hyaluronic Acid Gel on the Aging Signs of the Face versus Normal Saline: A Randomized, Double-blind, Placebo-controlled, Split-faced Study
Duteil L, Queille-Roussel C, Issa H, Sukmansaya N, Murray J, Fanian F. J Clin Aesthet Dermatol. 2023;16(2):29-36. PMID: 36909864
Supports: Split-face comparison of non-cross-linked hyaluronic acid and saline in 30 people
The Investigator found that NCHA either improved or much improved the aesthetic aspect on 82% of subjects whereas no improvement was found on the saline side.
Published 2026.10.20Last updated 2026.10.28