If nasolabial folds and hollow cheeks are your concern, should you get Juvelook Volume?
Juvelook Volume is a treatment in which PDLLA breaks down slowly and creates an environment for collagen production, so changes appear over time. Myongji Best Plastic Surgery Clinic in Myeongji-dong, Busan explains how to choose between it, fillers and lifting for nasolabial folds and hollow cheeks, what to check to lower nodule risk, the treatment interval and published fees.
Quick answer
At Myongji Best Plastic Surgery Clinic in Myeongji-dong, Busan, Juvelook is a treatment that injects PDLLA and hyaluronic acid into the dermis, and because PDLLA breaks down slowly and creates an environment for collagen production, nasolabial folds and hollow cheeks are not filled at once but improved over several sessions 3 to 4 weeks apart. If you are fine with hollow areas being corrected gradually over time, you can discuss Juvelook Volume; if you need volume correction whose shape shows right away, compare hyaluronic acid filler first, and if sagging skin is the cause, compare lifting first. Nodules have been reported to be linked to technique such as dilution and injection depth, so check the injection method and aftercare together before treatment.
Why it matters now
Because of its name, it is easy to expect Juvelook Volume to add volume right away like a filler, but its main ingredient, PDLLA, creates change over time, so judging it right after one session can make it feel as if it did not work. Nodules have also been reported after injections that stimulate collagen production, and the literature points to technique such as dilution and injection depth as causes, so you should first check how it will be injected as well as which concern it will be used for.
For nasolabial folds and hollow cheeks, should you look at Juvelook Volume, filler or lifting first?
If you are fine with hollow areas being corrected gradually over a few months, compare Juvelook Volume first; if you need volume correction whose shape shows right away, compare hyaluronic acid filler; and if the folds look deep because the cheeks have sagged, compare lifting. The manufacturer also explains that conventional hyaluronic acid filler corrects immediately through the volume of the injected gel, whereas Juvelook Volume is designed to give an initial physical effect with results that appear over time.
| If this is your situation | Option to consider | Evidence and limits |
|---|---|---|
| Want deep nasolabial folds or clearly hollow cheeks filled quickly | Option to considerHyaluronic acid filler | Evidence and limitsMyongji Best Plastic Surgery Clinic's filler page lists deep nasolabial folds, hollow cheeks and wanting quick volume improvement without surgery as target concerns. Duration is given as about 6 months to 1 year. |
| Fine with nasolabial folds and hollow cheeks being corrected gradually over time | Option to considerConsultation on Juvelook Volume | Evidence and limitsPDLLA breaks down slowly and creates an environment for collagen production, so change is gradual. In a 260-patient randomized study of a different PDLLA product, nasolabial fold improvement was no worse than with hyaluronic acid filler, but studies of Juvelook Volume itself are small. |
| The outer cheek below the cheekbone looks hollow | Option to considerCompare Juvelook Volume or filler | Evidence and limitsThere is a 24-patient case study in which Juvelook Volume was placed in the superficial fat layer with a cannula. It had no control group, and because the injection layer and tool differ by area, they are confirmed at consultation. |
| The forehead, temples or marionette lines look hollow | Option to considerCompare Juvelook Volume and filler for each area at consultation | Evidence and limitsThe manufacturer's overseas information lists the forehead and temples among the areas for Juvelook Volume, and Myongji Best Plastic Surgery Clinic's filler page lists the forehead, temples and other areas as filler treatment areas. Marionette lines are not specifically mentioned in the manufacturer's information, so this is judged at the visit. |
| Sagging cheeks seem to rest on top of the nasolabial folds | Option to considerCompare lifting | Evidence and limitsIf sagging skin is the cause, adding volume alone may leave the sagging. |
| Skin texture, pores, fine lines or sunken acne scars bother you more than hollowness | Option to considerCompare Juvelook Skin | Evidence and limitsThe clinic presents Juvelook for improving skin texture, fine lines, firmness, pores, skin tone, sunken areas and acne scars. |
How is Juvelook Volume different from Juvelook Skin?
The biggest differences are PDLLA content and intended use. According to the manufacturer's Korean product information, one vial of Juvelook Volume contains 170 mg of PDLLA and 30 mg of hyaluronic acid, more PDLLA than Juvelook (PDLLA 42.5 mg) or Juvelook Skin (PDLLA 25.5 mg), and the manufacturer's overseas information presents Juvelook as a product for skin rejuvenation and Juvelook Volume as a product for volume correction.
Ingredient content (manufacturer information)
Juvelook Skin is 30 mg (PDLLA 25.5 mg + hyaluronic acid 4.5 mg), Juvelook is 50 mg (PDLLA 42.5 mg + hyaluronic acid 7.5 mg) and Juvelook Volume is 200 mg (PDLLA 170 mg + hyaluronic acid 30 mg). Overseas literature also refers to Juvelook Volume as PDLLA-HA 200 (Lenisna).
Areas of use (manufacturer's overseas information)
Juvelook Volume is presented as a product for acne scars, the forehead, temples, nasolabial folds and facial sagging, and Juvelook for full-face skin rejuvenation, under-eye areas, acne scars and more. The manufacturer also states that approved indications may vary by country.
Injection layer
Myongji Best Plastic Surgery Clinic states that it injects Juvelook into the dermis. In studies, the injection layer varied by area, from intradermal (nasolabial folds) to the superficial fat layer (outer cheeks), so the injection layer for the area where Juvelook Volume will be used is confirmed at consultation.
How this relates to the clinic's fee items
Myongji Best Plastic Surgery Clinic's published non-covered fees list Juvelook Skin 4 cc (440,000 won per session) and Juvelook Volume 4 cc (495,000 won per session) separately. Which manufacturer product these items correspond to is confirmed at consultation.
Why doesn't Juvelook Volume fill in right away, and why might it feel like it didn't work?
Juvelook's PDLLA breaks down slowly in the skin and creates an environment for collagen production, so change appears over time, while hyaluronic acid helps add moisture right after treatment. Myongji Best Plastic Surgery Clinic recommends several sessions 3 to 4 weeks apart and says redness, swelling and bumps usually ease within a few days, so results are not judged by how the skin looks during this period.
Judging too early
The Juvelook studies reviewed evaluated results 3 months after completing 3 sessions. How the skin looks right after 1 or 2 sessions is not the final result.
Typical number of sessions and interval
Myongji Best Plastic Surgery Clinic recommends several Juvelook sessions 3 to 4 weeks apart, and the Juvelook studies reviewed also gave 3 sessions 3 to 4 weeks apart. How many sessions to have is decided at consultation based on the area and response.
When sagging is the cause
When sagging skin makes the nasolabial folds look deeper, the sagging may remain even after volume is added, so lifting is compared as well.
When a lot of volume is needed right away
Because this treatment shows change gradually, compare filler first if you need the shape created right away to meet a schedule.
Duration
No long-term duration data for Juvelook Volume itself were found. A study of a different PDLLA product followed nasolabial fold improvement for up to 52 weeks, and that product's expert consensus recommends maintenance treatment every 2 years, so about 1 to 2 years is generally used as a reference range, though it varies by product and person.
Why do Juvelook Volume nodules form, and what should you check to lower the risk?
Literature on PLLA, another collagen-stimulating injection, cites incorrect dilution, product that is not evenly mixed, injection that is too superficial and lack of post-treatment massage as causes of papules and nodules. Before getting Juvelook Volume, check the dilution method, injection layer and tool, risks specific to the area and the aftercare method.
Dilution
In Juvelook studies, one vial was diluted with 6 mL (nasolabial folds) or 8 mL (outer cheeks, Juvelook Volume) of saline, and an expert consensus on a different PDLLA product recommends dilution with 7 to 8 mL of sterile water for injection. Generally it falls in the range of 6 to 8 mL per vial and varies by area; the clinic's preparation method is confirmed at consultation.
Injection layer, tool and amount per area
The nasolabial fold study injected 1 mL per side intradermally, and the outer cheek study injected 4 mL per side into the superficial fat layer with a cannula. Check which layer will be used for your area and whether a needle or a cannula will be used.
Massage after treatment
PLLA literature cites lack of post-treatment massage as a cause of nodules, but Myongji Best Plastic Surgery Clinic advises avoiding vigorous face washing or massage on the day of Juvelook treatment. Because recommendations differ by product, do not massage on your own; follow the clinic's instructions.
Vascular complications
Although rare, an expert consensus states that Juvelook Volume can also cause visual impairment or blindness if injected into a blood vessel, and a literature review of biostimulator injectables reported 1 case of vision loss caused by PDLLA-HA. Check before treatment how emergencies are handled.
How does Myongji Best Plastic Surgery Clinic in Myeongji-dong, Busan perform Juvelook Volume, and what does it cost?
Myongji Best Plastic Surgery Clinic in Myeongji-dong, Gangseo-gu, Busan injects Juvelook into the dermis using numbing cream, adjusts the injection range and volume to skin condition and areas of concern, and recommends several sessions 3 to 4 weeks apart. Treatment time varies with the area covered, and it is used on wide areas such as the whole face, neck and backs of the hands.
The published non-covered fees list Juvelook Volume 4 cc at 495,000 won per session and 1,320,000 won for 3 sessions, and Juvelook Skin 4 cc at 440,000 won per session and 1,100,000 won for 3 sessions (checked November 2, 2026). Whether to use Juvelook Volume for nasolabial folds and hollow cheeks is decided at the visit, and the area that 4 cc covers and the number of sessions are also confirmed at consultation. Non-covered fees may change.
| Item | Published fee | Points to compare |
|---|---|---|
| Juvelook Volume 4 cc | Published fee1 session 495,000 won, 3 sessions 1,320,000 won | Points to compareSeveral sessions 3 to 4 weeks apart recommended |
| Juvelook Skin 4 cc | Published fee1 session 440,000 won, 3 sessions 1,100,000 won | Points to compareSeveral sessions 3 to 4 weeks apart recommended |
| Hyaluronic acid filler | Published feeRejuviel 1 cc 150,000 won, Belotero 1 cc 250,000 won | Points to compareDuration about 6 months to 1 year, recovery within 1 week |
Whether Juvelook Volume is suitable, and the formulation, volume and injection method, depend on the cause of hollowness and skin condition, so the diagnosis and guidance of your treating medical staff take priority over general information online. The typical intervals, durations and volumes in this article are reference values based on published studies and product information, and the exact values right for you are confirmed at consultation.
How much do Juvelook Volume's improvements in nasolabial folds and hollow cheeks, and its nodule rates, amount to in numbers?
Myongji Best Plastic Surgery Clinic has no published data on Juvelook Volume results or nodule statistics. The Juvelook studies were case studies of 20 patients with nasolabial folds and 24 with hollow outer cheeks, in which most were rated improved or better 3 months after the last session and no nodules were reported, while a larger randomized study reported that nasolabial fold improvement with a different PDLLA product was no worse than with hyaluronic acid filler.
Myongji Best Plastic Surgery Clinic data
Juvelook Volume treatment results and nodule statistics: no published data
Yi et al., 2026 (prospective case study, 20 patients with nasolabial folds)
One vial of Juvelook (PDLLA-HA) was diluted with 6 mL of saline and injected intradermally at 1 mL per fold into moderate or worse nasolabial folds, 3 times 1 month apart. Three months after the last session, 85% were rated improved or better and 90% reported high satisfaction; apart from temporary swelling and bruising, there were no nodules or granulomas. The abstract does not state whether the Skin or Volume formulation was used.
Yi et al., 2026 (consecutive case study, 24 patients with hollow outer cheeks)
Juvelook Volume was diluted with 8 mL of saline and injected with a cannula into the superficial fat layer at 4 mL per side, 3 times 3 weeks apart. At 3 months, 29.2% were very much improved, 45.8% much improved, 20.8% improved and 4.2% unchanged, and 87.5% were satisfied. Bruising occurred in 12.5% and resolved within 10 days, and there were no nodules, infections, granulomas or vascular complications.
Park et al., 2026 (randomized split-face, evaluator-blinded, 33 patients)
A product combining PDLLA and non-cross-linked hyaluronic acid was injected into one nasolabial fold and PLLA into the other, 3 times 4 weeks apart; both products significantly improved the folds, and the degree of improvement was similar. The abstract does not name the product, but the manufacturer cites this study as evidence for Juvelook Volume on nasolabial folds.
Ting et al., 2024 (randomized, evaluator-blinded, multicenter study, 260 patients)
A different PDLLA product (AestheFill) was compared with hyaluronic acid filler for nasolabial folds, with follow-up to 52 weeks. At 24 weeks, the share with at least a 1-grade improvement was 67.6% for PDLLA and 60.9% for hyaluronic acid, and there were no serious adverse events. It is a different product from Juvelook.
Lau et al., 2026 (expert consensus)
Because Juvelook Volume (PDLLA-HA 200) can rarely cause visual impairment and blindness if injected into a blood vessel, a panel of oculoplastic surgeons, dermatologists and aesthetic physicians set out safe injection techniques and a response protocol.
Young et al., 2026 (systematic review of vision loss from biostimulator injectables)
Reported vision loss included at least 11 cases with calcium hydroxylapatite, 2 with PLLA, 2 with PDLLA-CMC and 1 with PDLLA-HA. These are case counts reported in the literature, not incidence rates.
Narins, 2008 (literature review of PLLA injection)
It summarized that papules and nodules can result from incorrect dilution, uneven product distribution, injection that is too superficial and lack of post-treatment massage. It is an older review of PLLA products, which differ from Juvelook's PDLLA, so it cannot be applied directly.
Points to note when reading the figures
The two Juvelook case studies involved the same researcher, had 20 and 24 patients, had no control group and followed patients only up to 3 months after the last session. The larger randomized studies used other PDLLA products, so they cannot be applied directly to Juvelook Volume.
How should you care for your skin after Juvelook Volume, and when should you return to the clinic?
Myongji Best Plastic Surgery Clinic advises avoiding vigorous face washing or massage on the day of Juvelook treatment, refraining from alcohol, saunas, jjimjilbang and strenuous exercise for several days, keeping up moisturizing and sun protection, and minimizing irritation of the treated area. Redness, swelling and bumps usually ease within a few days; if a firm lump remains after that or symptoms get worse, be seen again.
What to do
Keep up moisturizing and sun protection, and check progress in line with the next session 3 to 4 weeks later.
What to avoid
Vigorous face washing and massage on the day of treatment; alcohol, saunas, jjimjilbang and strenuous exercise for several days after treatment
Reactions that settle within a few days
Redness, swelling, bumps
Signs to contact the clinic again
Contact the clinic where you were treated if a firm lump can still be felt or grows after several days, or if pain and redness keep getting worse. If your vision becomes blurred or you cannot see, get emergency care right away.
Frequently asked questions
Does Juvelook Volume work on nasolabial folds
In a 20-patient case study in which Juvelook (PDLLA-HA) was injected intradermally into nasolabial folds 3 times 1 month apart, 85% were rated as improved or better 3 months after the last session, and a 260-patient randomized study of a different PDLLA product also reported improvement no worse than with hyaluronic acid filler. Whether to use Juvelook Volume for nasolabial folds is decided at the visit, compared with filler, depending on whether the folds need to be filled quickly or can be corrected gradually.
What to do if a nodule forms after Juvelook Volume
If a firm lump can still be felt or grows after several days, do not press or massage it yourself; contact the clinic where you were treated and be seen. How it is treated is decided at the visit after the nodule is examined.
Why do people say Juvelook Volume has no effect
Juvelook's PDLLA breaks down slowly and creates an environment for collagen production, so there may be little change right after one session, and Myongji Best Plastic Surgery Clinic recommends several sessions 3 to 4 weeks apart. In a 24-patient study of hollow lateral cheeks, 1 patient (4.2%) still showed no change 3 months after 3 sessions, and if sagging skin is the cause, adding volume alone has limits.
About the clinic behind this article
Myongji Best Plastic Surgery Clinic is a board-certified plastic surgery clinic in Myeongji-dong, Gangseo-gu, Busan. Dr. Hyungseok Noh, board-certified plastic surgeon and medical director, provides care.
- Address
- Units 302–305, Building 1, 3 Myeongji-gukje 2-ro 28beon-gil, Gangseo-gu, Busan
- Main Line
- 051-711-7991
- Clinic Hours
- Weekdays AM 10:00 ~ PM 07:30Saturday AM 10:00 ~ PM 03:00Sundays & Public Holidays Closed
- Treatment guide
- View the Juvelook page
- Booking
- Naver Booking
REFERENCES
References
This article uses the clinic’s published information together with authoritative medical sources.
- Myongji Best Plastic Surgery ClinicJuvelook information — treatment method
Supports: That Juvelook is a treatment injecting PDLLA and hyaluronic acid into the dermis
A skin booster that injects PDLLA and hyaluronic acid into the dermis.
- Myongji Best Plastic Surgery ClinicJuvelook information — role of the ingredients
Supports: PDLLA's gradual creation of an environment for collagen production; hyaluronic acid's moisture support right after treatment
PDLLA breaks down slowly in the skin and creates an environment for collagen production, and hyaluronic acid helps add moisture right after treatment.
- Myongji Best Plastic Surgery ClinicJuvelook information — target concerns
Supports: Target concerns for Juvelook
It may help improve skin texture, fine lines, firmness, pores, skin tone, sunken areas and acne scars.
- Myongji Best Plastic Surgery ClinicJuvelook information — treatment areas
Supports: Use on the whole face, neck and backs of the hands; range and volume adjusted to condition
It can be used on wide areas such as the whole face, neck and backs of the hands, with the range and volume adjusted to the condition.
- Myongji Best Plastic Surgery ClinicJuvelook information — treatment interval and anesthesia
Supports: Several sessions 3 to 4 weeks apart, numbing cream, treatment time depending on range
Several sessions 3 to 4 weeks apart are recommended, using numbing cream. Treatment time depends on the range.
- Myongji Best Plastic Surgery ClinicJuvelook information — recovery period
Supports: When redness, swelling and bumps settle after treatment
Redness, swelling and bumps usually ease within a few days
- Myongji Best Plastic Surgery ClinicJuvelook information — aftercare
Supports: No vigorous face washing or massage on the day; refrain from alcohol, saunas, jjimjilbang and strenuous exercise for several days; moisturizing and sun protection; minimizing irritation
Please avoid vigorous face washing or massage on the day, please refrain from alcohol, saunas, jjimjilbang and strenuous exercise for several days, please keep up enough moisturizing and sun protection, please minimize irritation of the treated area
- Myongji Best Plastic Surgery ClinicFiller information — treatment method
Supports: That filler corrects lost volume in hollow areas with hyaluronic acid
Hyaluronic acid filler is injected into hollow or indented areas to make up for lost volume.
- Myongji Best Plastic Surgery ClinicFiller information — target concerns
Supports: Nasolabial folds, hollow cheeks and quick volume improvement listed as filler target concerns
When deep nasolabial folds are a concern, when hollow cheeks make the cheekbones look prominent, when you want quick volume improvement without surgery
- Myongji Best Plastic Surgery ClinicFiller information — treatment areas
Supports: Filler treatment areas such as the forehead and temples
It is applied after checking the structure of each area, such as the forehead, temples, nose, lips, cheeks and chin.
- Myongji Best Plastic Surgery ClinicFiller information — duration and recovery
Supports: Filler duration about 6 months to 1 year, recovery within 1 week
Duration is given as about 6 months to 1 year, and recovery as within 1 week.
- Myongji Best Plastic Surgery ClinicInformation on non-covered medical fees
Supports: Published fees for Juvelook Skin and Volume 4 cc (1 and 3 sessions) and Rejuviel and Belotero 1 cc
Juvelook Skin 4 cc 1 session 440,000 won, Juvelook Skin 4 cc 3 sessions 1,100,000 won, Juvelook Volume 4 cc 1 session 495,000 won, Juvelook Volume 4 cc 3 sessions 1,320,000 won, Rejuviel 1 cc 1 session 150,000 won, Belotero 1 cc 1 session 250,000 won
- VAIM (manufacturer)JUVELOOK product information (Korea)
Supports: PDLLA and hyaluronic acid content per vial of Juvelook Skin, Juvelook and Juvelook Volume
JUVELOOK SKIN 30mg PDLLA(25.5mg) + HA(4.5mg), JUVELOOK 50mg PDLLA(42.5mg) + HA(7.5mg), JUVELOOK Volume 200mg PDLLA(170mg) + HA(30mg)
- VAIM (manufacturer)JUVELOOK Lineup (overseas, export)
Supports: Areas of use for Juvelook and Juvelook Volume in the manufacturer's overseas information; the study cited as evidence for Juvelook Volume on nasolabial folds
JUVE LOOK, PDLLA 42.5mg + HA 7.5mg, Skin rejuvenation(full face), Tear trough, Acne scars, JUVE LOOK Volume, PDLLA 170mg + HA 30mg, Acne Scars, Forehead, Temples, Nasolabial Folds, Facial Sagging, 12. Park JY, et al. Skin Res Technol. 2026;32(1):e70324.
- VAIM (manufacturer)JUVELOOK FAQ (overseas, export)
Supports: Differences from hyaluronic acid filler; differences in indications by country
Traditional hyaluronic acid fillers primarily provide immediate correction through the physical volume of the injected gel. … Approved indications, product names, and availability may vary by country.
- PubMedA Clinical Study on the Efficacy and Safety of Injectable PDLLA for Nasolabial Fold Correction: Juvelook treatment for Nasolabial fold
Yi KH, Rosellini I, Min JLJ, Kim HS. J Craniofac Surg. 2026. Online ahead of print. doi:10.1097/SCS.0000000000012819. PMID: 42479568
Supports: Improvement and adverse events after 3 intradermal injections of Juvelook (PDLLA-HA) in 20 patients with nasolabial folds; dilution and injection volume
At 3 months posttreatment, 85% of patients were rated as "improved" or "much improved" on the GAIS, while 90% reported high satisfaction. Standardized photography confirmed a visible reduction in fold depth and enhanced facial contour. The procedure was well tolerated, with only transient swelling and bruising reported; no nodules, granulomas, or delayed adverse events were observed.
- PubMedPoly D,L Lactic Acid Injection for Subzygomatic Arch Depression (Lateral Sunken Cheek)
Yi KH, Rosellini I, Lee S, et al. J Craniofac Surg. 2026. Online ahead of print. doi:10.1097/SCS.0000000000013147. PMID: 42640663
Supports: Improvement and adverse events after cannula injection of Juvelook Volume into the superficial fat layer in 24 patients with hollow outer cheeks; dilution and injection volume
At 3 months, GAIS was rated very much improved in 7 (29.2%), much improved in 11 (45.8%), improved in 5 (20.8%), and no change in 1 (4.2%). Median GAIS score was 2 (much improved) and differed significantly from the no‑change score (Wilcoxon test versus 4; P<0.001). Twenty‑one patients (87.5%) were satisfied or very satisfied. Transient ecchymosis occurred in 3 patients (12.5%) and resolved within 10 days; no nodules, infections, granulomas, or vascular events were observed.
- PubMedA Split Face Study Comparing the Effect of a PDLLA Based Product and PLLA on the Nasolabial Fold (NLF)
Park JY, Im DJ, Jeon HD, et al. Skin Res Technol. 2026;32(1):e70324. doi:10.1111/srt.70324. PMID: 41532837
Supports: 33-patient randomized split-face study: nasolabial fold improvement with a PDLLA and non-cross-linked hyaluronic acid product versus PLLA
Both the PDLLA based product and PLLA significantly improved NLF wrinkle severity at all time points compared to baseline (p < 0.001). The degree of improvement was comparable between the two products throughout the observation period.
- PubMedA Randomized, Evaluator-Blinded, Multicenter Study to Compare Injectable Poly-D,L-Lactic Acid vs Hyaluronic Acid for Nasolabial Fold Augmentation
Ting W, Chong Y, Long X, et al. Aesthet Surg J. 2024;44(12):NP898-NP905. doi:10.1093/asj/sjae180. PMID: 39178357
Supports: 260-patient randomized study: nasolabial fold improvement with a different PDLLA product versus hyaluronic acid filler, 52-week follow-up
At 24 weeks, 67.6% of patients in the PDLLA group had an at least 1-grade improvement on the WSRS, compared to 60.9% of patients in the control group with an at least 1-grade improvement on the WSRS (P < .05). At each visit, the PDLLA group showed more improvement on the baseline WSRS than the control group. PDLLA was safe and well tolerated, with no severe adverse events.
- PubMedConsensus Recommendations for the Reconstitution and Aesthetic Use of Poly-D,L-Lactic Acid Microspheres
Magacho-Vieira FN, Vieira AO, Soares A Jr, et al. Clin Cosmet Investig Dermatol. 2024;17:2755-2765. doi:10.2147/CCID.S497691. PMID: 39654687
Supports: Dilution volume (7 to 8 mL) and maintenance interval (2 years) for a different PDLLA product (AestheFill)
Key recommendations include reconstitution with 7-8 mL of sterile water for injection, the addition of lidocaine to improve patient comfort, and a preference for targeting the superficial subcutaneous layer. Dosing guidelines are specifically tailored to each treatment area and the desired degree of correction, underscoring the importance of personalized treatment plans. Maintenance treatments are advised at biennial intervals or at shorter intervals for patients exhibiting accelerated collagen degradation.
- PubMedConsensus Opinion on Safe Injection Technique and Management of PDLLA-HA200-Induced Visual Impairment
Lau KHE, Young S, Goh A, et al. J Craniofac Surg. 2026;37(5):1103-1109. doi:10.1097/SCS.0000000000012271. PMID: 41359890
Supports: Risk of visual impairment and blindness from intravascular injection of Juvelook Volume (PDLLA-HA 200), and expert consensus
One rare but devastating complication is visual field impairment and blindness due to inadvertent intravascular injection. Recognizing the need for a dedicated consensus on the management of PDLLA-HA-induced visual impairment, a panel of experts comprising oculoplastic surgeons, dermatologists, and aesthetic physicians was convened to give a consensus on safe practice with PDLLA-HA 200 (Juvelook Volume/Lenisna) and develop a management algorithm for the management of PDLLA-HA-induced blindness.
- PubMedVisual Loss in Biostimulator Injectables: A Review of Incidence, Risk Factors, Etiology and Management Proposal
Young SM, Goh ASC, Jeyabal P, Ooi ASH. Aesthetic Plast Surg. 2026;50(5):1994-2005. doi:10.1007/s00266-025-05418-2. PMID: 41263987
Supports: Number of reported vision-loss cases by biostimulator injectable
CaHA has at least 11 published cases of vascular occlusion causing visual impairment, most involving the nasal dorsum. PLLA has two confirmed reports of visual loss, one from injection to periorbital/nasal region, and another from injection to the temple. PDLLA- carboxy-methylcellulose (CMC) has two reported cases of visual loss, one from injection to the forehead, another from injection to glabella region. PDLLA-HA has one reported case of visual loss from posterior ischemic optic neuropathy (PION).
- PubMedMinimizing adverse events associated with poly-L-lactic acid injection
Narins RS. Dermatol Surg. 2008;34 Suppl 1:S100-S104. doi:10.1111/j.1524-4725.2008.34250.x. PMID: 18547172
Supports: Dilution, distribution, injection depth and massage factors linked to papules and nodules after PLLA injection
Undesired AEs, such as papules and nodules, may result from incorrect reconstitution, uneven product distribution in the suspension, imprecise injection technique (superficial injection), or lack of posttreatment massage.
Published 2026.11.03Last updated 2026.11.03