Rejuran or Juvelook: Which Fits My Skin Concern?
Rejuran is a skin booster that injects salmon DNA-derived PN into the dermis, and Juvelook injects PDLLA and hyaluronic acid. Myongji Best Plastic Surgery Clinic in Myeongji-dong, Busan compares the two head to head: selection criteria by main concern (texture and inner dryness versus pores, elasticity, and pitted scars), treatment schedules, published fees, and whether they can be combined.
Quick answer
If rough texture, inner dryness, and fine lines are the main concern, PN-based Rejuran is considered first; if enlarged pores, loss of elasticity, and pitted acne scars are concerns together, Juvelook with PDLLA and hyaluronic acid is considered first. Both are injected into the dermis after numbing cream and bring gradual change; Juvelook is recommended in several sessions 3 to 4 weeks apart, while Rejuran has no fixed interval in the clinic's published material, so the number of sessions is decided in consultation. Whether to receive both is not covered in the clinic's published material and is decided in consultation based on skin condition.
Why it matters now
Rejuran and Juvelook are both skin boosters injected into the dermis, but their main ingredients differ, PN versus PDLLA and hyaluronic acid, so the direction of expected change differs. Which product is considered first depends on whether the problem is skin condition, such as texture and inner dryness, or one that needs a collagen-forming environment, such as pores, elasticity, and pitted areas. Both bring gradual change over several sessions, so which concern is bigger should be decided before starting.
Which is your main concern: texture and inner dryness, or pores, elasticity, and pitted scars?
If texture has become rough and inner dryness and fine lines bother you, Rejuran is considered first; if enlarged pores, loss of elasticity, and pitted acne scars are concerns together, Juvelook is. Fine lines around the eyes are a target for both, but the eye-specific formulation is Rejuran I, and Juvelook is considered for wider areas including the neck and backs of the hands.
| If this is your situation | Approach to consider | Evidence and limits |
|---|---|---|
| Rough texture with inner dryness, fine lines, and loss of elasticity across the face | Approach to considerRejuran Healer (PN) | Evidence and limitsMyongji Best Plastic Surgery Clinic presents Rejuran Healer as the basic line for overall facial skin condition. There is no fixed interval in the published material, so the number of sessions is decided in consultation. |
| Inner dryness and dullness, with worry about injection pain | Approach to considerRejuran HB (PN + hyaluronic acid + lidocaine) | Evidence and limitsA formulation that adds hyaluronic acid and lidocaine to PN. How much pain is felt varies from person to person. |
| Enlarged pores, loss of elasticity, and pitted acne scars together | Approach to considerJuvelook (PDLLA + hyaluronic acid) | Evidence and limitsPDLLA breaks down slowly in the skin and induces a collagen-forming environment, so change is gradual. Deep scars and adhesions may need other treatments as well. |
| Fine lines under the eyes and thinning eye-area skin | Approach to considerRejuran I (eye-specific formulation) or Juvelook | Evidence and limitsRejuran I is an eye-specific formulation, and Juvelook is also indicated for fine lines around the eyes and forehead. Which one fits is decided in consultation along with the thickness of the eye-area skin. |
| Wanting to treat the neck and backs of the hands as well as the face | Approach to considerJuvelook | Evidence and limitsMyongji Best Plastic Surgery Clinic uses Juvelook on wide areas such as the whole face, neck, and backs of the hands. Volume and treatment time vary with the area. |
| Wanting to fill a hollow right away or lift sagging | Approach to considerNeither treatment applies | Evidence and limitsRejuran and Juvelook do not create immediate volume or lift sagging, so fillers or lifting are compared first. |
How do Rejuran's PN and Juvelook's PDLLA and hyaluronic acid differ?
Rejuran injects PN extracted and purified from salmon DNA into the dermis, and Juvelook injects PDLLA and hyaluronic acid. PN conditions the skin's regenerative environment to manage texture, inner dryness, fine lines, and elasticity together, PDLLA breaks down slowly and induces a collagen-forming environment, and hyaluronic acid supplements hydration right after treatment.
PN (Rejuran)
An ingredient extracted and purified from salmon DNA; Healer, HB, I, or S is chosen by concern and area. Anyone with a fish allergy must say so before the consultation.
PDLLA (Juvelook)
It breaks down slowly in the skin and induces a collagen-forming environment. Change is therefore assessed over time rather than right after treatment.
Hyaluronic acid (Juvelook, Rejuran HB)
In Juvelook it supplements hydration right after treatment; in Rejuran HB it is added to PN together with lidocaine to address inner dryness and pain at the same time.
What the two treatments share
Both are injected into the dermis and neither is a filler that creates immediate volume. Bumps or swelling right after treatment are not judged as the effect.
How do the treatment schedule and the timing of results differ?
Juvelook is assessed after several sessions 3 to 4 weeks apart, while Rejuran has no fixed interval or session count in the clinic's published material, so when to assess results is decided in consultation. Both aim for gradual change, so the state right after one session is not judged as the final result.
Rejuran schedule
No fixed interval or duration is stated in the published material, so the number of sessions and the assessment point are decided in consultation by product and area.
Juvelook schedule
Several sessions 3 to 4 weeks apart are recommended, and single-session and three-session plans are listed separately in the published non-covered fee list.
Assessment points seen in research
In a 30-subject study of a PN product injected three times 4 weeks apart, improvement persisted up to the six-month visit, and a 16-patient study of a PDLLA and non-crosslinked hyaluronic acid combination assessed change after 2 to 3 sessions 4 weeks apart.
How does Myongji Best Plastic Surgery Clinic perform the two treatments, and how do the costs differ?
Myongji Best Plastic Surgery Clinic injects both into the dermis after applying numbing cream. Rejuran proceeds in the order of consultation and diagnosis, cleansing, numbing cream, dermal injection, and soothing care, with Healer, HB, I, or S chosen; for Juvelook, the injection area and volume are adjusted to skin condition and the area of concern, and treatment time varies with the area.
The fees below are from Myongji Best Plastic Surgery Clinic's published non-covered fee list (verified October 22, 2026). They vary by product, volume, and treatment area, so the total cost, including whether numbing cream and soothing care are included, is confirmed in consultation, and non-covered fees are subject to change.
| Item | Published fee | Notes |
|---|---|---|
| Rejuran HB 2cc | Published feeKRW 450,000 | NotesFormulation adding hyaluronic acid and lidocaine to PN |
| Rejuran I 1cc | Published feeKRW 159,000 | NotesEye-specific formulation |
| Rejuran Healer and Rejuran S | Published feeNo published fee | NotesConfirmed in consultation |
| Juvelook Skin 4cc | Published fee1 session KRW 440,000, 3 sessions KRW 1,100,000 | NotesSeveral sessions recommended 3 to 4 weeks apart |
| Juvelook Volume 4cc | Published fee1 session KRW 495,000, 3 sessions KRW 1,320,000 | NotesSkin or Volume formulation decided in consultation |
Can Rejuran and Juvelook be received together?
Myongji Best Plastic Surgery Clinic's published material contains no guidance on combining Rejuran and Juvelook on the same day or in the same area, so whether and in what order to combine them is decided in consultation based on skin condition. No published study comparing the effect or safety of receiving both was directly verified either.
Both are dermal injections, so reactions such as stinging, redness, swelling, bruising, and bumps can overlap; the clinic advises avoiding saunas and strenuous exercise for about 7 days after Rejuran and alcohol, saunas, spas, and strenuous exercise for several days after Juvelook. Starting one, checking the reaction and change, and then reassessing the need for the other is easier to manage in terms of cost and recovery.
Suitability, whether to combine them, and the product and volume depend on skin condition and the medical staff's judgement, so your medical staff's diagnosis and guidance take priority over general information online.
What do the numbers say about the actual effects and side effects of Rejuran and Juvelook?
Myongji Best Plastic Surgery Clinic has no published statistics on Rejuran or Juvelook results or side effects. No study directly comparing PN and PDLLA was found; in separate small studies, skin elasticity, hydration, and texture measures improved and no serious adverse events were reported.
Myongji Best Plastic Surgery Clinic data
Treatment results and side effect statistics: no published data
Lee et al., 2022 (PN, randomized double-blind split-face, 27 subjects)
A PN filler and a non-crosslinked hyaluronic acid filler were injected on opposite sides of the periocular area three times at two-week intervals. Global aesthetic improvement scores did not differ between the two groups, improvement rates for elasticity, hydration, roughness, and pores were higher on the PN side, and there were no serious adverse events.
Lim et al., 2024 (PN, single-arm, 30 Asian subjects)
After three injections of a PN product 4 weeks apart, skin surface, firmness, pigmentation, and radiance improved significantly and persisted to six months, with no adverse events. It is a PN product other than Rejuran, and there was no control group.
Seo et al., 2024 (PDLLA, preliminary study, 16 patients)
After 2 to 3 injections of a PDLLA and non-crosslinked hyaluronic acid combination 4 weeks apart, fine wrinkles, texture, pigmentation, and erythema changed significantly, 50% reported more than 50% overall improvement, and there were no severe adverse events. It is a small study without a control group.
Points to keep in mind about the numbers
All are small studies of 30 subjects or fewer, none compares PN with PDLLA, and the study products and injection methods differ from the clinic's treatments, so they cannot be applied directly.
Frequently asked questions
What is the difference between Rejuran and Juvelook
Rejuran injects PN extracted and purified from salmon DNA into the dermis, and Juvelook injects PDLLA and hyaluronic acid. Rejuran is used to manage texture, inner dryness, fine lines, and elasticity, while Juvelook is used to gradually manage pores, elasticity, pitted areas, and acne scars.
Which is more expensive, Rejuran or Juvelook
Based on the published non-covered fee list (verified October 22, 2026), Rejuran HB 2cc is KRW 450,000 and Rejuran I 1cc KRW 159,000, while Juvelook Skin 4cc is KRW 440,000 per session and Juvelook Volume 4cc KRW 495,000 per session. Volumes and recommended session counts differ, so the total cost for the planned number of sessions, not the single-session price, should be compared in consultation.
Which is better for pores, Rejuran or Juvelook
Myongji Best Plastic Surgery Clinic recommends Juvelook when enlarged pores and loss of elasticity are concerns together. The Rejuran page does not list pores as a target concern, but a periocular PN study of 27 subjects reported a higher improvement rate in pore volume than on the hyaluronic acid side, so it can be compared in consultation when texture is also a concern.
About the clinic behind this article
Myongji Best Plastic Surgery Clinic is a board-certified plastic surgery clinic in Myeongji-dong, Gangseo-gu, Busan. Dr. Hyungseok Noh, board-certified plastic surgeon and medical director, provides care.
- Address
- Units 302–305, Building 1, 3 Myeongji-gukje 2-ro 28beon-gil, Gangseo-gu, Busan
- Main Line
- 051-711-7991
- Clinic Hours
- Weekdays AM 10:00 ~ PM 07:30Saturday AM 10:00 ~ PM 03:00Sundays & Public Holidays Closed
- Treatment guide
- View Rejuran page
- Booking
- Naver Booking
REFERENCES
References
This article uses the clinic’s published information together with authoritative medical sources.
- Myongji Best Plastic Surgery ClinicRejuran guide
Supports: PN ingredient and injection layer, target concerns, uses of Healer, HB, I, and S, anesthesia and procedure order, aftercare
Rejuran is a skin booster that injects PN extracted and purified from salmon DNA into the dermis. It addresses skin texture, inner dryness, fine lines, and loss of elasticity together and can help restore overall skin condition.
- Myongji Best Plastic Surgery ClinicJuvelook guide
Supports: Roles of PDLLA and hyaluronic acid, target concerns and treatment areas, the 3-to-4-week schedule, anesthesia, recovery, aftercare
PDLLA breaks down slowly in the skin and induces a collagen-forming environment, while hyaluronic acid helps supplement hydration right after treatment. Several sessions 3 to 4 weeks apart are recommended, and numbing cream is used.
- Myongji Best Plastic Surgery ClinicInformation on non-covered medical fees
Supports: Published fees for Rejuran HB and I and Juvelook Skin and Volume
Juvelook Skin 4cc 1 session KRW 440,000, Juvelook Volume 4cc 1 session KRW 495,000, Rejuran HB 2cc KRW 450,000, Rejuran I 1cc KRW 159,000
- PubMedComparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial
Lee YJ, Kim HT, Lee YJ, et al. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. J Dermatolog Treat. 2022;33(1):254-260. doi:10.1080/09546634.2020.1748857. PMID: 32248707
Supports: Improvement rates for elasticity, hydration, roughness, and pores in a 27-subject randomized double-blind study comparing periocular PN and non-crosslinked hyaluronic acid
The improvement rates of roughness and pore volume were higher in the PN group than in the HA group. The improvement rate of dermal density was not significantly different between the groups. No serious adverse events were reported.
- PubMedPolynucleotides HPT for Asian Skin Regeneration and Rejuvenation
Lim TS, Liew S, Tee XJ, et al. Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation. Clin Cosmet Investig Dermatol. 2024;17:417-431. doi:10.2147/CCID.S437942. PMID: 38371328
Supports: Single-arm study following 30 Asian subjects for six months after three PN injections 4 weeks apart
PN HPT treatment led to a meaningful and statistically significant improvement of the skin surface, firmness, pigmentation, and radiance, with no early- or late-onset adverse events and benefits persisting up to the sixth-month visit in all subjects.
- PubMedSkin rejuvenation effect of the combined PDLLA and non cross-linked hyaluronic acid: A preliminary study
Seo SB, Park H, Jo JY, Ryu HJ. Skin rejuvenation effect of the combined PDLLA and non cross-linked hyaluronic acid: A preliminary study. J Cosmet Dermatol. 2024;23(3):794-802. doi:10.1111/jocd.16085. PMID: 37969055
Supports: Improvement responses and safety in a 16-patient preliminary study of a PDLLA and non-crosslinked hyaluronic acid combination injected 2 to 3 times 4 weeks apart
All participants received two or three procedure sessions with a 4 weeks interval between sessions. Half (50%) of patients responded that there was more than 50% overall improvement. There were no severe adverse events.
Published 2026.10.23Last updated 2026.10.23