Should You Get Rejuran I for Fine Lines and Thinning Skin Under the Eyes?
Rejuran I (Rejuran Eye) is an eye-area formulation used for fine lines under the eyes and thinning skin around the eyes. Myongji Best Plastic Surgery Clinic in Myeongji-dong, Busan summarizes how to tell it apart from bulging under-eye fat and hollows, figures from eye-area PN studies, the treatment process and published costs.
Quick answer
Myongji Best Plastic Surgery Clinic in Myeongji-dong, Busan uses Rejuran I (Rejuran Eye), an eye-area formulation, for fine lines under the eyes, thinning skin around the eyes and reduced firmness around the eyes, so if your concern falls within this range, Rejuran I can be considered. On the other hand, if under-eye fat bulges out or the under-eye area is deeply hollow and casts a shadow, compare surgery such as under-eye fat repositioning or volume-restoring options before Rejuran I.
Why it matters now
Under-eye concerns such as fine lines, thinning skin, bulging fat, hollowing and pigmentation tend to overlap and look like a single problem. If the main cause of the shadow is bulging fat or a deep hollow, repeating only injections that manage skin texture is unlikely to bring the change you expect, and cost and time can simply add up. That is why you should first identify which cause matters most before deciding on Rejuran I.
How can I tell whether Rejuran I fits my under-eye concern?
If your main concern is more fine lines under the eyes, or skin around the eyes that has thinned or lost firmness, consider Rejuran I. If the cause lies in structure or color rather than the skin itself, such as a shadow from bulging fat, a deeply sunken groove or brown pigmentation, look first at the option that fits that cause.
| If this is your situation | Option to consider | Evidence and limits |
|---|---|---|
| More fine lines under the eyes, with skin around the eyes thinning or losing firmness | Option to considerRejuran I (Rejuran Eye) | Evidence and limitsMyongji Best Plastic Surgery Clinic uses Rejuran I to manage fine lines under the eyes, thinning skin around the eyes and reduced firmness around the eyes. Most studies of eye-area PN injections are small and have no control group. |
| Under-eye fat bulges out and casts a shadow, or the lower eyelid sags | Option to considerConsultation for surgery such as under-eye fat repositioning or lower eyelid surgery | Evidence and limitsA systematic review of 50 studies considered surgery the first choice for bulging fat and weak lower eyelid support. Bulging fat is also not among the concerns the clinic lists for Rejuran I. |
| The under-eye area is deeply hollow, with a clear groove and shadow | Option to considerSeparate consultation on volume-restoring options | Evidence and limitsThe same review concluded that fillers are the foundation for volume loss, while PN targets texture and fine lines. Which method the clinic uses for under-eye hollows is confirmed at consultation. |
| The under-eye area looks brownish-dark or blood vessels show through | Option to considerCheck for pigment or vascular causes first | Evidence and limitsThe same review regarded lasers as effective for melanin and visible blood vessels, and peels and topical treatments as effective for superficial pigment irregularities. An observational study (61 people) reported that dark circles lightened with a different PN product, but it had no control group, and dark circles are not among the concerns the clinic lists for Rejuran. |
| Fine lines together with bulging fat or hollowing | Option to considerStep-by-step consultation that sets priorities by cause | Evidence and limitsThe review concluded that under-eye concerns arise from multiple causes and require an individualized treatment plan. The order of treatments and whether to combine them are decided at the clinic. |
What does Rejuran I do for under-eye skin, and what can it not do?
Rejuran I is a treatment that injects PN into the dermis around the eyes to manage the condition of the skin itself, such as fine lines, thinning skin and reduced firmness. It does not move bulging fat or fill deeply hollow areas, so if these are the main cause, compare other options first.
The under-eye area has some of the thinnest skin on the face. In a study that measured dermal thickness at several facial areas by ultrasound (31 people), the lower eyelid averaged 0.53 mm, the thinnest of the areas measured, while the temple and posterior cheek measured 1.18 mm. Myongji Best Plastic Surgery Clinic describes Rejuran I as an eye-area formulation used to care for this delicate area around the eyes.
If you are unsure whether Rejuran I or Juvelook suits you, the differences in ingredients and treatment cycles between the two are covered separately in our Rejuran vs. Juvelook article.
How is Rejuran I done at Myongji Best Plastic Surgery Clinic, and how much does it cost?
Myongji Best Plastic Surgery Clinic in Myeongji-dong, Gangseo-gu, Busan checks your skin condition and areas of concern at consultation, then chooses among Healer, HB, I and S the product that fits your skin concern and treatment area. For the eye area it uses Rejuran I, an eye-area formulation; after cleansing, numbing cream is applied, the product is injected into the dermis, and the session finishes with soothing care.
The published non-covered fees list Rejuran I 1cc at KRW 159,000 per session (checked November 2, 2026). The volume the clinic uses for both eye areas and the treatment interval and number of sessions are not stated in the published information, so they are confirmed at consultation along with the total cost, and non-covered fees may change.
- STEP 01
Consultation and assessment
Your skin condition and areas of concern are checked.
- STEP 02
Cleansing
The skin is cleansed before treatment.
- STEP 03
Numbing cream
Numbing cream is applied to prepare for treatment.
- STEP 04
Dermal injection
The selected product is injected into the dermis.
- STEP 05
Soothing care
Soothing skin care follows the injections.
As general figures, in a survey of 235 Korean dermatologists, the most common recommendation was 3 PN injection sessions at 4-week intervals. In a study that injected a different PN product under the eyes (61 people), 3 sessions at 2-3 week intervals were used, usually 1 mL per side for 2 mL on both sides, with smaller amounts also allowed. Intervals and volumes differ between studies, so the number of sessions and volume right for you are decided at the clinic.
If bulging under-eye fat is your main concern, you can compare candidates and recovery in our under-eye fat repositioning article, together with the fat repositioning KRW 1.2 million and lower eyelid surgery KRW 1.8 million items in the same published fee list.
What do the numbers show about the actual results and side effects of eye-area PN injections?
Myongji Best Plastic Surgery Clinic has no published statistics on Rejuran I results or side effects. Most studies of eye-area PN injections are small with no control group, and they used PN products other than Rejuran I.
Myongji Best Plastic Surgery Clinic data
Rejuran I treatment results and side-effect statistics: no published data
Ziade et al., 2026 (prospective observational study, 42 people)
Forty-two people seeking under-eye improvement received intradermal injections of a different PN product (Pluryal Silk, 7.5mg/mL) at 2mL per session. Patient-rated scores for the lower eyelid and crow's feet improved over baseline at every time point (1, 3 and 6 months), with the greatest improvement and satisfaction at 3 months after 2 sessions. Few adverse events were reported, but there was no control group.
Kim et al., 2022 (single-arm, 28 of 30 completed)
PN filler was injected into the wrinkles at the outer corners of the eyes (crow's feet), and at the assessment 18 weeks after the first injection the wrinkle grade had improved over baseline, as had wrinkles, texture, pores and depressions measured with a 3D camera. This study looked at crow's feet rather than the under-eye area, the abstract does not name the product, and there was no control group.
Beer et al., 2026 (systematic review, 50 studies)
It organized 50 studies of under-eye treatments by treatment type and classified PN as suited to texture and fine lines, fillers to volume loss, and surgery to bulging fat and weak lower eyelid support. The abstract does not present figures comparing the effects of individual products.
Points to note when reading the figures
None of the three sources evaluated Rejuran I directly, and the individual studies had 50 people or fewer with no control group, so their results cannot be applied directly to treatment at the clinic.
How should I care for my skin after Rejuran I, and when should I return to the clinic?
According to the clinic, redness, swelling and bruising may appear temporarily and usually ease within a few days. Keep face washing and makeup to a minimum on the day of treatment, avoid saunas and strenuous exercise for about 7 days, and be thorough with sun protection.
On the day of treatment
Keep face washing and makeup to a minimum.
Avoid for about 7 days
Saunas and strenuous exercise
Keep doing
Be thorough with sun protection.
Signs to contact the clinic right away
When redness, swelling or bruising does not settle after a few days or keeps getting worse, or when warmth or pus develops
When to consult again
If the under-eye shadow is unchanged after several sessions, check again whether bulging fat or hollowing is the main cause.
Reactions to and effects of Rejuran I vary with the skin condition around the eyes and the underlying cause, so the assessment and guidance you receive at the clinic take priority over online information. The general cycles, durations and volumes in this article are reference values based on published studies and product information, and the exact values right for you are confirmed at consultation.
Frequently asked questions
How long does Rejuran I last
Studies generally report that improvement was maintained up to the 6-month follow-up. In a study in which 30 Asian participants received a different PN product 3 times at 4-week intervals, the effect was maintained in all participants up to the 6-month visit, and in a 42-person observational study of the under-eye area, scores were also better than before treatment up to 6 months. Data beyond 6 months are limited and neither study had a control group, so the timing of repeat treatment is decided at consultation based on your progress.
Does Rejuran I hurt a lot
Myongji Best Plastic Surgery Clinic applies numbing cream before Rejuran treatment. Even so, because the product is injected into the dermis, some stinging may occur, and how much you feel varies from person to person.
When do Rejuran I bumps go away
The small raised spots that appear at the injection points right after treatment are commonly called bumps (embo). Myongji Best Plastic Surgery Clinic's published information does not state how long bumps take to settle; it advises that redness, swelling and bruising usually ease within a few days. If the raised spots remain after a few days, have them checked at the clinic.
About the clinic behind this article
Myongji Best Plastic Surgery Clinic is a board-certified plastic surgery clinic in Myeongji-dong, Gangseo-gu, Busan. Dr. Hyungseok Noh, board-certified plastic surgeon and medical director, provides care.
- Address
- Units 302–305, Building 1, 3 Myeongji-gukje 2-ro 28beon-gil, Gangseo-gu, Busan
- Main Line
- 051-711-7991
- Clinic Hours
- Weekdays AM 10:00 ~ PM 07:30Saturday AM 10:00 ~ PM 03:00Sundays & Public Holidays Closed
- Treatment guide
- View the Rejuran page
- Booking
- Naver Booking
REFERENCES
References
This article uses the clinic’s published information together with authoritative medical sources.
- Myongji Best Plastic Surgery ClinicRejuran guide · Rejuran I
Supports: That Rejuran I is an eye-area formulation used to manage fine lines under the eyes, thinning skin around the eyes and reduced firmness around the eyes
Used to care for delicate areas, such as fine lines under the eyes, thinning skin around the eyes and reduced firmness around the eyes.
- Myongji Best Plastic Surgery ClinicRejuran guide · Treatment information
Supports: Dermal injection of PN, product choice among Healer, HB, I and S, numbing cream, and the sequence from consultation to soothing care
Consultation and assessment → Cleansing → Numbing cream → Dermal injection → Soothing care
- Myongji Best Plastic Surgery ClinicRejuran guide · Aftercare
Supports: Temporary redness, swelling and bruising that ease within a few days, minimal face washing and makeup on the day, no saunas or strenuous exercise for about 7 days, sun protection
Redness, swelling and bruising may appear temporarily and usually ease within a few days
- Myongji Best Plastic Surgery ClinicNon-covered fee information
Supports: Published fees for Rejuran I 1cc, fat repositioning and lower eyelid surgery
Rejuran I 1cc KRW 159,000, fat repositioning KRW 1.2 million, lower eyelid surgery KRW 1.8 million
- PubMedWhat's New With Under Eye Treatment: A Multispecialty Systematic Review of Recent Under Eye Treatments
Beer J, Boghosian T, Sherif R, et al. Dermatol Surg. 2026;52(2):155-163. doi:10.1097/DSS.0000000000004964. PMID: 41615388
Supports: Systematic review of 50 studies on under-eye treatment: treatment classification by concern (PN, fillers, lasers, surgery) and the need for individualized treatment plans
Fillers remain foundational for volume loss; lasers address melanin, vascularity, and skin laxity. Microneedling and polynucleotides target texture and fine rhytides. Chemical peels and topicals are effective for superficial dyschromia. Botulinum toxin benefits orbicularis oculi hypertrophy and sequelae. Surgery is preferred for herniated fat and poor lower eyelid support.
- PubMedProspective Observational Study of Polynucleotide Injections for Periorbital Rhytides
Ziade G, Keyrouz E, El Maalouf J, et al. J Cosmet Dermatol. 2026;25(2):e70736. doi:10.1111/jocd.70736. PMID: 41689167
Supports: 6-month patient ratings and adverse events in a prospective observational study of 42 people who received intradermal injections of a different PN product for under-eye improvement
Significant improvements in lower eyelid and crow's feet appraisal scores were observed at all follow-up time points compared with baseline (p < 0.001).
- PubMedEffects of Polynucleotide Dermal Filler in the Correction of Crow's Feet Using an Antera Three-Dimensional Camera
Kim JH, Kim ES, Kim SW, Hong SP, Kim J. Aesthetic Plast Surg. 2022;46(4):1902-1909. doi:10.1007/s00266-022-02832-8. PMID: 35357558
Supports: Wrinkle grade and 3D camera-measured improvement in a single-arm study of crow's feet in 30 people (28 completed)
Improvements in wrinkles, pores, texture, depression, and Hb level after polynucleotide filler injection were verified by objective and subjective evaluations.
- PubMedAnalysis of Dermal Thickness Across 10 Areas and Injection Depth After Polynucleotide Injection Using Rejumate Automatic 0.8-mm 9-pin Injector on the Face Using 33-MHz Sonography
Kim JS, Atchima S. Plast Reconstr Surg Glob Open. 2025;13(9):e7121. doi:10.1097/GOX.0000000000007121. PMID: 41000432
Supports: Finding from ultrasound measurements in 31 people that lower eyelid dermis was the thinnest
The average dermal thickness across regions ranged from 0.53 (lower eyelid) to 1.18 mm (temple and posterior cheek).
- PubMedA survey on the cosmetic use of injectable polynucleotide: The pattern of practice among Korean Dermatologists
Rho NK, Han KH, Cho M, Kim HS. J Cosmet Dermatol. 2024;23(4):1243-1252. doi:10.1111/jocd.16125. PMID: 38093498
Supports: The PN injection schedule most often recommended in a survey of 235 Korean dermatologists (3 sessions at 4-week intervals), and under-eye fine lines as a leading indication
A total of three sessions of PN injection spaced 4 weeks apart is most often recommended.
- PubMedA Real-World Study of Polynucleotides HPT for Treating Periorbital Hyperpigmentation
Amado R, Al-Mukhtar Y, Lanza E, et al. Clin Cosmet Investig Dermatol. 2026;19:605046. doi:10.2147/CCID.S605046. PMID: 42164086
Supports: Injection interval (3 sessions at 2-3 week intervals), volume (1 mL per side) and reported pigment improvement in a 61-person observational study of under-eye dark circles
PN HPT hydrogel (7.5 mg/mL) in phosphate buffer was administered with needle or cannula at baseline (T0), after two to three weeks (second injection, T1), and two to three weeks after T1 (third injection, T2); usually 1 mL on the right periorbicular area and 1 mL on the left (lower doses allowed at the specialist's discretion).
- PubMedPolynucleotides HPT for Asian Skin Regeneration and Rejuvenation
Lim TS, Liew S, Tee XJ, et al. Clin Cosmet Investig Dermatol. 2024;17:417-431. doi:10.2147/CCID.S437942. PMID: 38371328
Supports: Finding that the effect was maintained up to the 6-month visit after 30 Asian participants received a PN preparation 3 times at 4-week intervals
The aesthetic benefits persisted up to the sixth-month visit in all subjects.
Published 2026.11.03Last updated 2026.11.03